![]() Activation of Wnt/β-catenin signaling suppressed expressions of tenogenic genes of Scx, Mkx, and Tnmd in rat tendon-derived cells (TDCs) isolated from the Achilles tendons of 6-week old rats. ![]() We found that the number of β-catenin-positive cells was increased at the injured site, suggesting involvement of Wnt/β-catenin signaling in tendon healing. In contrast, the roles of Wnt/β-catenin signaling in tendon remain mostly elusive. The roles of TGF-β signaling in tendon homeostasis and tendon development have been elucidated. Modulation of signaling pathways, which are involved in tendon development and tendon repair, is one of attractive modalities to facilitate proper regeneration of the injured tendon. After tendon injuries, biomechanical properties of the injured tendon are not fully recovered in most cases.
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